The NASAC network leadership structure consists of the General Assembly, the Board, the Secretariat, and Executive Directors from the member academies.
The General Assembly is the overall decision making body of NASAC and is comprised of the Presidents of the member academies. The NASAC Board is the Executive arm of NASAC and it is constituted of a Chair, 3 Vice Chairs, Secretary General and the Treasurer. For the period 2008-2013, the NASAC Board will comprise of:
- Chair - Academy of Sciences of South Africa;
- Vice Chair (i) Vice Chair for Policy Review and Administration - Nigerian Academy of Science (ii) Vice Chair for Public Relations and Outreach - Uganda National Academy of Sciences (iii) Vice Chair for Resource Mobilization and Fund Raising - Hassan II Academy of Science and Technology Morocco
- Secretary General - Acadermie des Sciences et Techniques du Senegal; and
- Treasurer - African Academy of Sciences
The NASAC Secretariat, which is currently based at the African Academy of Sciences (AAS), is responsible for the formal functions and legal operations of the network.